The Tumor Necrosis Factor α (-308 A/G) Polymorphism Is Associated with Cystic Fibrosis in Mexican Patients
$ 19.50 · 5 (669) · In stock
Environmental and genetic factors may modify or contribute to the phenotypic differences observed in multigenic and monogenic diseases, such as cystic fibrosis (CF). An analysis of modifier genes can be helpful for estimating patient prognosis and directing preventive care. The aim of this study is to determine the association between seven genetic variants of four modifier genes and CF by comparing their corresponding allelic and genotypic frequencies in CF patients (n = 81) and control subjects (n = 104). Genetic variants of MBL2 exon 1 (A, B, C and D), the IL-8 promoter (−251 A/T), the TNFα promoter (TNF1/TNF2), and SERPINA1 (PI*Z and PI*S) were tested in CF patients and control subjects from northeastern Mexico by PCR-RFLP. Results The TNF2 allele (P = 0.012, OR 3.43, 95% CI 1.25–9.38) was significantly associated with CF under the dominant and additive models but was not associated with CF under the recessive model. This association remained statistically significant after adjusting for multiple tests using the Bonferroni correction (P = 0.0482). The other tested variants and genotypes did not show any association with the disease. Conclusion An analysis of seven genetic variants of four modifier genes showed that one variant, the TNF2 allele, appears to be significantly associated with CF in Mexican patients.
PDF) Tumor necrosis factor-alpha promoter polymorphism in Mexican patients with Chagas' disease
PDF] A trial sequential meta-analysis of TNF-α –308G>A (rs800629) gene polymorphism and susceptibility to colorectal cancer
Steroid 5 alpha-reductase 2 enzyme variants, biomass exposure and tobacco use in Mexican patients with prostate cancer
Mutations included in the kits used for the molecular diagnosis of CF
Cells, Free Full-Text
Macrophage-derived cytokines in pneumonia: Linking cellular immunology and genetics - ScienceDirect
Genetic Modifying Factors of Cystic Fibrosis Phenotype: A Challenge for Modern Medicine. - Abstract - Europe PMC
PDF] CFTR allelic heterogeneity in Mexican patients with cystic fibrosis: implications for molecular screening.
Cells, Free Full-Text
CFTR Sequence Variants Identified in Five Comprehensive CFTR Studies in
Tumor necrosis factor (TNF)-α- 308 G/A gene polymorphism (rs1800629) in Egyptian patients with alopecia areata and vitiligo, a laboratory and in silico analysis
A meta-analysis for association of TNF-α -308G>A polymorphism with susceptibility to Ankylosing Spondylitis - ScienceDirect
Fibrogenic Polymorphisms (TGF-β, PAI-1, AT) in Mexican Patients with Established Liver Fibrosis. Potential Correlation with Pirfenidone Treatment - Juan Armendáriz-Borunda, Ana Rosa Rincón, José Francisco Muñoz-Valle, Miriam Bueno-Topete, Edith Oregón
Cancers, Free Full-Text