Physical mechanisms explaining DNA and RNA twist changes

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The double-helix structure of DNA is deformed by environmental stimuli, which will then affect gene expression, and eventually trigger a sequence of cellular processes. Recent research led by a physicist from City University of Hong Kong (CityU) observed substantial DNA deformations by ions and temperature changes. The researchers developed one simple physical model to explain DNA deformations. These results provide new insights into the molecular mechanisms of cellular responses to ions and temperature changes and can be used to control gene expression using ions and temperature.